Inositol-phosphate phosphatase
| inositol-1(or 4)-monophosphatase | |||||||
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| Identifiers | |||||||
| EC number | 3.1.3.25 | ||||||
| CAS number | 37184-63-7 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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In enzymology, an inositol-phosphate phosphatase (EC 3.1.3.25) is an enzyme that catalyzes the chemical reaction
- myo-inositol phosphate + H2O
myo-inositol + phosphate
Thus, the two substrates of this enzyme are myo-inositol phosphate and H2O, whereas its two products are myo-inositol and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is myo-inositol-phosphate phosphohydrolase. Other names in common use include myo-inositol-1(or 4)-monophosphatase, inositol 1-phosphatase, L-myo-inositol-1-phosphate phosphatase, myo-inositol 1-phosphatase, inositol phosphatase, inositol monophosphate phosphatase, inositol-1(or 4)-monophosphatase, myo-inositol-1(or 4)-phosphate phosphohydrolase, myo-inositol monophosphatase, and myo-inositol-1-phosphatase. This enzyme participates in 3 metabolic pathways: streptomycin biosynthesis, inositol phosphate metabolism, and phosphatidylinositol signaling system.
Structural studies
As of late 2007, 26 structures have been solved for this class of enzymes, with PDB accession codes 1AWB, 1DK4, 1G0H, 1G0I, 1IMA, 1IMB, 1IMC, 1IMD, 1IME, 1IMF, 1LBV, 1LBW, 1LBX, 1LBY, 1LBZ, 2BJI, 2CZH, 2CZI, 2CZK, 2DDK, 2FVZ, 2HHM, 2P3N, 2P3V, 2PCR, and 2QFL.
References
- Eisenberg F Jr (1967). "D-myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis". J. Biol. Chem. 242 (7): 1375–82. PMID 4290245.
- Shute JK; Ragan, CI; Watling, KJ; Aspley, S; Jackson, RG; Reid, GG; Gani, D; Shute, JK (1988). "The purification and properties of myo-inositol monophosphatase from bovine brain". Biochem. J. 249 (3): 883–9. PMC 1148789. PMID 2833231. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1148789.
- Hallcher LM, Sherman WR (1980). "The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain". J. Biol. Chem. 255 (22): 10896–901. PMID 6253491.
- Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD (1997). "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder". Mol. Psychiatry. 2 (5): 393–7. doi:10.1038/sj.mp.4000325. PMID 9322233.
- Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of Phosphoinositides, Oxford, 2000, p. 320-338.
- Ackermann KE, Gish BG, Honchar MP, Sherman WR (1987). "Evidence that inositol 1-phosphate in brain of lithium-treated rats results mainly from phosphatidylinositol metabolism". Biochem. J. 242 (2): 517–24. PMC 1147736. PMID 3036092. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1147736.
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